The Ca2+-releasing messenger NAADP, a new player in the nervous system - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Physiology - Paris Année : 2006

The Ca2+-releasing messenger NAADP, a new player in the nervous system

Résumé

Many physiological processes are controlled by a great diversity of Ca2+ signals. Within cell, Ca2+ signals depend upon Ca2+ entry and/or Ca2+ release from internal Ca2+ stores. The control of Ca2+-store mobilization is ensured by a family of messengers comprising inositol 1,4,5 trisphosphate, cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate (NAADP). From recent works, new concepts have emerged where activation of the cells by outside stimuli, acting at the plasma membrane, results in the synthesis of multiple Ca2+-releasing messengers which may interact and shape complex Ca2+ signals in the cytosol as well as in the nucleus. This contribution will cover the most recent advances on NAADP signalling with some emphasis on neurons.

Dates et versions

hal-00022279 , version 1 (05-04-2006)

Identifiants

Citer

Stéphanie Bezin, Gilles Charpentier, Philippe Fossier, José-Manuel Cancela. The Ca2+-releasing messenger NAADP, a new player in the nervous system. Journal of Physiology - Paris, 2006, 99(2-3), pp.111-118. ⟨10.1016/j.jphysparis.2005.12.007⟩. ⟨hal-00022279⟩
20 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More