Neuroprotection following repeated hypoxia preconditioning (RHP): pivotal role of brain-derived erythropoietin - Archive ouverte HAL Access content directly
Preprints, Working Papers, ... Year : 2006

Neuroprotection following repeated hypoxia preconditioning (RHP): pivotal role of brain-derived erythropoietin

Abstract

Hypoxic preconditioning is a process by which prior treatment of a sublethal dose of hypoxia renders cells tolerant to otherwise lethal hypoxia insult. In the brain, one of the key mediators of this neuroprotective effect is the brain-derived erythropoietin (EPO). Neuroprotection can be mimicked by systemic administration of elevated dose of recombinant EPO (rEPO), which unfortunately presents adverse effects when used frequently on the long-term in patients at risk to cerebral insults because of its peripheral hypertensive and pro-thrombic effects. Therefore, to moderate the use of rEPO, long-lasting physiological elevation of EPO expression within vulnerable brain areas is proposed as a promising approach to reinforce neuronal robustness. The objectives of this project are to define within a model of repeated hypoxia preconditioning the fundamentals mechanisms underlying neuroprotective effects of brain-derived EPO.
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Dates and versions

hal-00022216 , version 1 (05-04-2006)

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  • HAL Id : hal-00022216 , version 1

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Laurent Bezin. Neuroprotection following repeated hypoxia preconditioning (RHP): pivotal role of brain-derived erythropoietin. 2006. ⟨hal-00022216⟩
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