Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue European Journal of Medicinal Chemistry Année : 2006

Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives.

Résumé

In the course of structure–activity relationship studies, diversely substituted 1-(β-d-glucopyranosyl)-isoindigo derivatives were prepared from commercially available indolines. Their antiproliferative activities were evaluated toward a panel of human solid cancer cell lines (PC 3, DLD-1, MCF-7, M4Beu, A549, PA 1), a murine cell line (L929) and a human fibroblast primary culture to get an insight into the substitution pattern required for the best biological potencies

Domaines

Chimie organique
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Dates et versions

hal-00020445 , version 1 (27-02-2007)

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Mathieu Sassatelli, Fadoua Bouchikhi, Samir Messaoudi, Fabrice Anizon, Eric Debiton, et al.. Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives.. European Journal of Medicinal Chemistry, 2006, 41, pp.88-100. ⟨10.1016/j.ejmech.2005.10.004⟩. ⟨hal-00020445⟩
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