<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-00013610</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-03T14:05:21+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Parasitism of iron-siderophore receptors of Escherichia coli by the siderophore-peptide microcin E492m</title>
            <author role="aut">
              <persName>
                <forename type="first">D.</forename>
                <surname>Destoumieux-Garzón</surname>
              </persName>
              <email type="md5">cab17a2d01286b472df2e708e4171b0d</email>
              <email type="domain">ifremer.fr</email>
              <idno type="idhal" notation="string">ddestoum</idno>
              <idno type="idhal" notation="numeric">180396</idno>
              <idno type="halauthorid" notation="string">117318-180396</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8793-9138</idno>
              <idno type="IDREF">https://www.idref.fr/14886497X</idno>
              <affiliation ref="#struct-19260"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">J.</forename>
                <surname>Peduzzi</surname>
              </persName>
              <email type="md5">58feed622e1864478671164fd2b7384b</email>
              <email type="domain">mnhn.fr</email>
              <idno type="idhal" notation="numeric">830869</idno>
              <idno type="halauthorid" notation="string">116702-830869</idno>
              <affiliation ref="#struct-19260"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">X.</forename>
                <surname>Thomas</surname>
              </persName>
              <idno type="halauthorid">117320-0</idno>
              <affiliation ref="#struct-19260"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">C.</forename>
                <surname>Goulard</surname>
              </persName>
              <idno type="halauthorid">116763-0</idno>
              <affiliation ref="#struct-19260"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">A.</forename>
                <surname>Blond</surname>
              </persName>
              <idno type="halauthorid">116391-0</idno>
              <affiliation ref="#struct-19260"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">C.</forename>
                <surname>Afonso</surname>
              </persName>
              <idno type="halauthorid">73615-0</idno>
              <affiliation ref="#struct-1143"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">J.-C.</forename>
                <surname>Tabet</surname>
              </persName>
              <email type="md5">9d170c9fb9fdf7f54002241aef7d18d4</email>
              <email type="domain">ccr.jussieu.fr</email>
              <idno type="idhal" notation="numeric">1207512</idno>
              <idno type="halauthorid" notation="string">117339-1207512</idno>
              <idno type="IDREF">https://www.idref.fr/070390991</idno>
              <idno type="VIAF">https://viaf.org/viaf/195977563</idno>
              <idno type="ISNI">http://isni.org/isni/0000000139120059</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0080-2946</idno>
              <affiliation ref="#struct-1143"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">N.</forename>
                <surname>Birlirakis</surname>
              </persName>
              <idno type="halauthorid">116786-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">S.</forename>
                <surname>Rebuffat</surname>
              </persName>
              <email type="md5">4f61e50a5b890469e0fb91af165a2ae0</email>
              <email type="domain">mnhn.fr</email>
              <idno type="idhal" notation="numeric">1441831</idno>
              <idno type="halauthorid" notation="string">116511-1441831</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5257-5039</idno>
              <affiliation ref="#struct-19260"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Jean</forename>
                <surname>Peduzzi</surname>
              </persName>
              <email type="md5">58feed622e1864478671164fd2b7384b</email>
              <email type="domain">mnhn.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2005-11-09 15:04:33</date>
              <date type="whenModified">2025-01-23 11:00:34</date>
              <date type="whenReleased">2005-11-09 15:04:33</date>
              <date type="whenProduced">2005-06</date>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="116194">
                <persName>
                  <forename>Jean</forename>
                  <surname>Peduzzi</surname>
                </persName>
                <email type="md5">58feed622e1864478671164fd2b7384b</email>
                <email type="domain">mnhn.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-00013610</idno>
            <idno type="halUri">https://hal.science/hal-00013610</idno>
            <idno type="halBibtex">destoumieuxgarzon:hal-00013610</idno>
            <idno type="halRefHtml">&lt;i&gt;7th International symposium on microbial iron transport storage and metabolism&lt;/i&gt;, Jun 2005, Paris, France</idno>
            <idno type="halRef">7th International symposium on microbial iron transport storage and metabolism, Jun 2005, Paris, France</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="MNHN">Muséum National d'Histoire Naturelle</idno>
            <idno type="stamp" n="UPMC" corresp="SORBONNE-UNIVERSITE">Université Pierre et Marie Curie</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno>
            <idno type="stamp" n="SU-SCIENCES" corresp="SORBONNE-UNIVERSITE">Faculté des Sciences de Sorbonne Université</idno>
            <idno type="stamp" n="SU-SCI" corresp="SORBONNE-UNIVERSITE">Sciences - Sorbonne Université</idno>
            <idno type="stamp" n="ALLIANCE-SU"> Alliance Sorbonne Université</idno>
            <idno type="stamp" n="TEST2-HALCNRS">TEST2-HALCNRS</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="1">Not set</note>
            <note type="invited" n="0">No</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
            <note type="proceedings" n="0">No</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Parasitism of iron-siderophore receptors of Escherichia coli by the siderophore-peptide microcin E492m</title>
                <author role="aut">
                  <persName>
                    <forename type="first">D.</forename>
                    <surname>Destoumieux-Garzón</surname>
                  </persName>
                  <email type="md5">cab17a2d01286b472df2e708e4171b0d</email>
                  <email type="domain">ifremer.fr</email>
                  <idno type="idhal" notation="string">ddestoum</idno>
                  <idno type="idhal" notation="numeric">180396</idno>
                  <idno type="halauthorid" notation="string">117318-180396</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8793-9138</idno>
                  <idno type="IDREF">https://www.idref.fr/14886497X</idno>
                  <affiliation ref="#struct-19260"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">J.</forename>
                    <surname>Peduzzi</surname>
                  </persName>
                  <email type="md5">58feed622e1864478671164fd2b7384b</email>
                  <email type="domain">mnhn.fr</email>
                  <idno type="idhal" notation="numeric">830869</idno>
                  <idno type="halauthorid" notation="string">116702-830869</idno>
                  <affiliation ref="#struct-19260"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">X.</forename>
                    <surname>Thomas</surname>
                  </persName>
                  <idno type="halauthorid">117320-0</idno>
                  <affiliation ref="#struct-19260"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">C.</forename>
                    <surname>Goulard</surname>
                  </persName>
                  <idno type="halauthorid">116763-0</idno>
                  <affiliation ref="#struct-19260"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">A.</forename>
                    <surname>Blond</surname>
                  </persName>
                  <idno type="halauthorid">116391-0</idno>
                  <affiliation ref="#struct-19260"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">C.</forename>
                    <surname>Afonso</surname>
                  </persName>
                  <idno type="halauthorid">73615-0</idno>
                  <affiliation ref="#struct-1143"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">J.-C.</forename>
                    <surname>Tabet</surname>
                  </persName>
                  <email type="md5">9d170c9fb9fdf7f54002241aef7d18d4</email>
                  <email type="domain">ccr.jussieu.fr</email>
                  <idno type="idhal" notation="numeric">1207512</idno>
                  <idno type="halauthorid" notation="string">117339-1207512</idno>
                  <idno type="IDREF">https://www.idref.fr/070390991</idno>
                  <idno type="VIAF">https://viaf.org/viaf/195977563</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000139120059</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0080-2946</idno>
                  <affiliation ref="#struct-1143"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">N.</forename>
                    <surname>Birlirakis</surname>
                  </persName>
                  <idno type="halauthorid">116786-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">S.</forename>
                    <surname>Rebuffat</surname>
                  </persName>
                  <email type="md5">4f61e50a5b890469e0fb91af165a2ae0</email>
                  <email type="domain">mnhn.fr</email>
                  <idno type="idhal" notation="numeric">1441831</idno>
                  <idno type="halauthorid" notation="string">116511-1441831</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5257-5039</idno>
                  <affiliation ref="#struct-19260"/>
                </author>
              </analytic>
              <monogr>
                <meeting>
                  <title>7th International symposium on microbial iron transport storage and metabolism</title>
                  <date type="start">2005-06</date>
                  <settlement>Paris</settlement>
                  <country key="FR">France</country>
                </meeting>
                <imprint>
                  <date type="datePub">2005-06</date>
                </imprint>
              </monogr>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv.bbm.bc">Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM]</classCode>
              <classCode scheme="halTypology" n="COMM">Conference papers</classCode>
              <classCode scheme="halOldTypology" n="COMM">Conference papers</classCode>
              <classCode scheme="halTreeTypology" n="COMM">Conference papers</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Microcins are gene-encoded antibacterial peptides secreted by enterobacteria. They are believed to play a major role in the microbial competitions within the intestinal tract. We have recently isolated a posttranslationally modified form of the 84-residue microcin E492 named MccE492m. MccE492m posttranslational modification was characterized as a trimer of N-(2,3-dihydroxybenzoyl)-L-serine (DHBS) linked to the Ser84-carboxylate via a beta-D-glucose moiety. MccE492m was shown to bind iron through the trimer of DHBS. This is the first example of a novel type of antibacterial peptide called siderophore-peptide. Recognition of both modified and unmodified MccE492 was shown to be mediated by the FepA, Cir and Fiu iron-siderophore receptors at the outer membrane of E. coli. However, the siderophore-mimicking modification was shown to significantly improve the microcin activity. Thus, we propose that MccE492 and MccE492m parasitize iron-siderophore receptors for uptake into the target bacteria and that improvement of MccE492 antimicrobial activity upon modification results from an increase in the microcin/receptor affinity.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-19260" status="OLD">
          <idno type="RNSR">200311830A</idno>
          <orgName>Laboratoire de chimie et biochimie des substances naturelles</orgName>
          <date type="start">2003-01-01</date>
          <date type="end">2008-12-31</date>
          <desc>
            <address>
              <addrLine>Département Régulations, Développement et Diversité Moléculaire (RDDM) - 57 rue Cuvier - CP 54 - 75005 Paris</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="USM502" active="#struct-7512" type="direct"/>
            <relation name="UMR5154" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1143" status="OLD">
          <orgName>Synthèse, Structure et Fonction de Molécules Bioactives</orgName>
          <orgName type="acronym">SSFMB</orgName>
          <desc>
            <address>
              <addrLine>aile 44-45 - 3ème etg 4 Place Jussieu 75252 PARIS CEDEX 05</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.labos.upmc.fr/umr7613/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-93591" type="direct"/>
            <relation active="#struct-341038" type="direct"/>
            <relation name="UMR7613" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-7512" status="VALID">
          <idno type="IdRef">026394944</idno>
          <idno type="ROR">https://ror.org/03wkt5x30</idno>
          <orgName>Muséum national d'Histoire naturelle</orgName>
          <orgName type="acronym">MNHN</orgName>
          <desc>
            <address>
              <addrLine>57, rue Cuvier - 75231 Paris Cedex 05</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.mnhn.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-93591" status="OLD">
          <idno type="ROR">https://ror.org/02en5vm52</idno>
          <orgName>Université Pierre et Marie Curie - Paris 6</orgName>
          <orgName type="acronym">UPMC</orgName>
          <date type="end">2017-12-31</date>
          <desc>
            <address>
              <addrLine>4 place Jussieu - 75005 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.upmc.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-341038" status="VALID">
          <idno type="IdRef">232435103</idno>
          <idno type="ISNI">000000010626358X</idno>
          <idno type="ROR">https://ror.org/02cte4b68</idno>
          <orgName>Institut de Chimie - CNRS Chimie</orgName>
          <orgName type="acronym">INC-CNRS</orgName>
          <date type="start">2009-10-01</date>
          <desc>
            <address>
              <addrLine>CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE3 rue Michel-Ange75794 PARIS CEDEX 16 - France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cnrs.fr/inc</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>