On the induction of postsynaptic granule cell-Purkinje neuron LTP and LTD. - Grenoble Institut des Neurosciences Accéder directement au contenu
Article Dans Une Revue The Cerebellum Année : 2010

On the induction of postsynaptic granule cell-Purkinje neuron LTP and LTD.

Résumé

In the last decade, several experimental studies have demonstrated that particular patterns of synaptic activity can induce postsynaptic parallel fiber (PF) long-term potentiation (LTP). This form of plasticity can reverse postsynaptic PF long-term depression (LTD), which has been traditionally considered as the principal form of plasticity underlying cerebellar learning. Postsynaptic PF-LTP requires a transient increase in intracellular Ca(2+) concentration and, in contrast to PF-LTD, is induced without concomitant climbing fiber (CF) activation. Thus, it has been postulated that the polarity of long-term synaptic plasticity is determined by the amplitude of the Ca(2+) transient during the induction protocol, with PF-LTP induced by smaller Ca(2+) signals without concomitant CF activation. However, this hypothesis is contradicted by recent studies. A quantitative analysis of Ca(2+) signals associated with induction of PF-LTP indicates that the bidirectional induction of long-term plasticity is regulated by more complex mechanisms. Here we review the state-of-the-art of research on postsynaptic PF-LTP and PF-LTD and discuss the principal open questions on this topic.
Fichier principal
Vignette du fichier
Vogt_2010_on_the_induction_the_cerebellum_auteur.pdf (331.09 Ko) Télécharger le fichier
inserm-00587870_edited.pdf (216.06 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

inserm-00587870 , version 1 (21-04-2011)

Identifiants

Citer

Kaspar E. Vogt, Marco Canepari. On the induction of postsynaptic granule cell-Purkinje neuron LTP and LTD.. The Cerebellum, 2010, 9 (3), pp.284-90. ⟨10.1007/s12311-010-0174-9⟩. ⟨inserm-00587870⟩

Collections

INSERM UGA U836
103 Consultations
374 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More