Structure-function strategies to improve the pharmacological value of animal toxins. - Archive ouverte HAL Access content directly
Book Sections Year : 2006

Structure-function strategies to improve the pharmacological value of animal toxins.

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Abstract

Animal venoms are rich sources of bioactive compounds that possess obvious pharmacological, therapeutic and/or biotechnological values. A majority of these compounds are peptides that mainly target enzymes, membrane receptors or ion channels. These peptides are most often in a size range that allows their production in vitro by chemical synthesis or genetic engineering. Unfortunately, they rarely display the required characteristics in terms of selectivity, affinity, stability and targeting with regard to the desired application. In recent years, a number of structural approaches or strategies have been developed to improve the intrinsic potential of venom peptides. They are reviewed herein for their effectiveness.
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Dates and versions

inserm-00394127 , version 1 (10-06-2009)

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Michel de Waard, Jean-Marc Sabatier. Structure-function strategies to improve the pharmacological value of animal toxins.. Abba J. Kastin. Peptides - Handbook of Biologically Active Peptides, Elsevier, pp.415-419, 2006, ⟨10.1016/B978-012369442-3/50062-3⟩. ⟨inserm-00394127⟩
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