Aluminum-[ 18 F]Fluoride Radiolabeling Optimization by Design of Experiments Approach (Présentation d'un Flash-Poster) - Laboratoire SYstèmes et Matériaux pour la MEcatronique Accéder directement au contenu
Communication Dans Un Congrès Année : 2022

Aluminum-[ 18 F]Fluoride Radiolabeling Optimization by Design of Experiments Approach (Présentation d'un Flash-Poster)

Résumé

Fluorine-18 (18F) is the most favorable positron emitter for tumor imaging. However, direct 18F labeling of biomolecules is challenging as it involves multiple steps and stringent conditions that are generally not suitable for biomolecules whose integrity may be altered. Over the past decade, an elegant new approach has been developed by coordination of aluminum fluoride {Al-18F}. The objective of this work was to optimize radiolabeling yield by applying a design of experiments (DoE) approach. To evaluate {Al-18F} complexation, NODA-MP-C4 was prepared as a model compound from the commercially available NODA-MP-NCS. This model bears a thiourea function to mimic that present in the final conjugates. The corresponding radioactive complex Al18F-NODA-MP-C4 was obtained following the most common reported radiofluorination conditions (acetate buffer, reflux). DoE was designed and analyzed using Ellistat® software (v6.8). Radiolabeling optimization by using a DoE approach was obtained with a satisfactory yield while reducing the number of experiments and improving radioprotection of workers.
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Dates et versions

hal-04055333 , version 1 (03-04-2023)

Identifiants

  • HAL Id : hal-04055333 , version 1

Citer

Carine San, Meriem Beddek, Fabienne Dioury, Nicolas Vignal, Benoît Hosten, et al.. Aluminum-[ 18 F]Fluoride Radiolabeling Optimization by Design of Experiments Approach (Présentation d'un Flash-Poster). 20th European Symposium on Radiopharmacy and Radiopharmaceuticals (ESRR’22), Nov 2022, Verona, Italy. ⟨hal-04055333⟩
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