Association of chorioamnionitis with cerebral palsy at two years after spontaneous very preterm birth: the epipage-2 cohort study - Archive ouverte HAL Access content directly
Journal Articles The Journal of Pediatrics Year : 2020

Association of chorioamnionitis with cerebral palsy at two years after spontaneous very preterm birth: the epipage-2 cohort study

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Abstract

To assess whether chorioamnionitis is associated with cerebral palsy (CP) or death at 2 years' corrected age in infants born before 32 weeks of gestation after spontaneous birth.EPIPAGE-2 is a national, prospective, population-based cohort study of children born preterm in France in 2011; recruitment periods varied by gestational age. This analysis includes infants born alive after preterm labor or preterm premature rupture of membranes from 240/76/7Among 2252 infants born alive spontaneously before 32 weeks of gestation, 116 (5.2%) were exposed to clinical chorioamnionitis. Among 1470 with placental examination data available, 639 (43.5%) had histologic chorioamnionitis. In total, 346 infants died before 2 years and 1586 (83.2% of the survivors) were evaluated for CP at age 2 years. CP rates were 11.1% with and 5.0% without clinical chorioamnionitis (P = .03) and 6.1% with and 5.3% without histologic chorioamnionitis (P = .49). After adjustment for confounding factors, CP risk rose with clinical chorioamnionitis (aOR 2.13, 95% CI 1.12-4.05) but not histologic chorioamnionitis (aOR 1.21, 95% 0.75-1.93). Neither form was associated with the composite outcome "CP or death at age 2."Among infants very preterm born spontaneously, the risk of CP at a corrected age of 2 years was associated with exposure to clinical chorioamnionitis but not histologic chorioamnionitis.
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hal-03405174 , version 1 (23-06-2022)

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Attribution - NonCommercial - CC BY 4.0

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Emeline Maisonneuve, Elsa Lorthe, Heloise Torchin, Pierre Delorme, Louise Devisme, et al.. Association of chorioamnionitis with cerebral palsy at two years after spontaneous very preterm birth: the epipage-2 cohort study. The Journal of Pediatrics, 2020, The Journal of pediatrics, 222, pp.71-78.e6. ⟨10.1016/j.jpeds.2020.03.021⟩. ⟨hal-03405174⟩
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