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Article Dans Une Revue The American Journal of Psychiatry Année : 2016

The Bidirectional Associations Between Psychotic Experiences and DSM-IV Mental Disorders

John Mcgrath
Sukanta Saha
  • Fonction : Auteur
Ali Al-Hamzawi
  • Fonction : Auteur
Laura Helena Andrade
  • Fonction : Auteur
  • PersonId : 908894
Corina Benjet
  • Fonction : Auteur
Evelyn Bromet
  • Fonction : Auteur
Mark Oakley Browne
  • Fonction : Auteur
Jose Caldas de Almeida
  • Fonction : Auteur
Wai Tat Chiu
  • Fonction : Auteur
Koen Demyttenaere
  • Fonction : Auteur
  • PersonId : 908899
John Fayyad
  • Fonction : Auteur
Silvia Florescu
  • Fonction : Auteur
Giovanni de Girolamo
Oye Gureje
Margreet ten Have
  • Fonction : Auteur
Chiyi Hu
  • Fonction : Auteur
Carmen C.W. Lim
  • Fonction : Auteur
Fernando Navarro-Mateu
  • Fonction : Auteur
Nancy Sampson
  • Fonction : Auteur
  • PersonId : 908896
Jose Posada-Villa
  • Fonction : Auteur
Kenneth Kendler
  • Fonction : Auteur
Ronald Kessler
  • Fonction : Auteur
  • PersonId : 908913

Résumé

OBJECTIVE: While it is now recognized that psychotic experiences are associated with an increased risk of later mental disorders, we lack a detailed understanding of the reciprocal time-lagged relationships between first onsets of psychotic experiences and mental disorders. Using data from World Health Organization World Mental Health (WMH) Surveys, the authors assessed the bidirectional temporal associations between psychotic experiences and mental disorders. METHOD: The WMH Surveys assessed lifetime prevalence and age at onset of psychotic experiences and 21 common DSM-IV mental disorders among 31,261 adult respondents from 18 countries. Discrete-time survival models were used to examine bivariate and multivariate associations between psychotic experiences and mental disorders. RESULTS: Temporally primary psychotic experiences were significantly associated with subsequent first onset of eight of the 21 mental disorders (major depressive disorder, bipolar disorder, generalized anxiety disorder, social phobia, posttraumatic stress disorder, adult separation anxiety disorder, bulimia nervosa, and alcohol abuse), with odds ratios ranging from 1.3 (95% CI=1.2-1.5) for major depressive disorder to 2.0 (95% CI=1.5-2.6) for bipolar disorder. In contrast, 18 of 21 primary mental disorders were significantly associated with subsequent first onset of psychotic experiences, with odds ratios ranging from 1.5 (95% CI=1.0-2.1) for childhood separation anxiety disorder to 2.8 (95% CI=1.0-7.8) for anorexia nervosa. CONCLUSIONS: While temporally primary psychotic experiences are associated with an elevated risk of several subsequent mental disorders, these data show that most mental disorders are associated with an elevated risk of subsequent psychotic experiences. Further investigation of the underlying factors accounting for these time-order relationships may shed light on the etiology of psychotic experiences.

Dates et versions

hal-02479048 , version 1 (14-02-2020)

Identifiants

Citer

John Mcgrath, Sukanta Saha, Ali Al-Hamzawi, Laura Helena Andrade, Corina Benjet, et al.. The Bidirectional Associations Between Psychotic Experiences and DSM-IV Mental Disorders. The American Journal of Psychiatry, 2016, 173 (10), pp.997-1006. ⟨10.1176/appi.ajp.2016.15101293⟩. ⟨hal-02479048⟩
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