<em>In vitro</em> adhesion properties of shiga toxin-producing <em>Escherichia coli</em> isolated from cattle, food, and humans - Archive ouverte HAL Access content directly
Journal Articles Frontiers in Microbiology Year : 2015

In vitro adhesion properties of shiga toxin-producing Escherichia coli isolated from cattle, food, and humans

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Abstract

Shiga toxin-producing Escherichia coli (STEC) are able to cause serious illnesses ranging from diarrhea to hemorrhagic colitis and hemolytic-uremic syndrome (HUS). These bacteria colonize the digestive tract of humans and produce Shiga-toxins, which are considered to be essential for virulence and are crucial in lethal infection. Colon colonization is supposed to be a determinant step in the development of the infection, but the virulence traits that mediate this step are unclear. We analyzed the ability of 256 STEC strains belonging to seropathotype A (the most virulent 0157:H7 serotype) to seropathotype E (not involved in human disease) to adhere to HEp-2, HCT-8, and T84 cell lines. Of the 256 STEC tested most (82%) were non-adherent in our assays. The adhesion levels were globally low and were not related to pathogenicity, although the highest levels were associated to 026:H11 and 0103:H2 strains of seropathotype B (associated with HUS but less commonly than serotype 0157:H7), possessing both the eae and toxB genes.
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hal-02636431 , version 1 (27-05-2020)

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Nathalie Pradel, Lucie Etienne Mesmin, Jonathan Thevenot, Charlotte Cordonnier, Stephanie Blanquet Diot, et al.. In vitro adhesion properties of shiga toxin-producing Escherichia coli isolated from cattle, food, and humans. Frontiers in Microbiology, 2015, 6, ⟨10.3389/fmicb.2015.00156⟩. ⟨hal-02636431⟩
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