Exploiting the full potential of proton therapy: An update on the specifics and innovations towards spatial or temporal optimisation of dose delivery - Laboratoire de Physique Corpusculaire de Caen Accéder directement au contenu
Article Dans Une Revue Cancer/Radiothérapie Année : 2020

Exploiting the full potential of proton therapy: An update on the specifics and innovations towards spatial or temporal optimisation of dose delivery

Résumé

Prescription and delivery of protons are somewhat different compared to photons and may influence outcomes (tumour control and toxicity). These differences should be taken into account to fully exploit the clinical potential of proton therapy. Innovations in proton therapy treatment are also required to widen the therapeutic window and determine appropriate populations of patients that would benefit from new treatments. Therefore, strategies are now being developed to reduce side effects to critical normal tissues using alternative treatment configurations and new spatial or temporal-driven optimisation approaches. Indeed, spatiotemporal optimisation (based on flash, proton minibeam radiation therapy or hypofractionated delivery methods) has been gaining some attention in proton therapy as a mean of improving (biological and physical) dose distribution. In this short review, the main differences in planning and delivery between protons and photons, as well as some of the latest developments and methodological issues (in silico modelling) related to providing scientific evidence for these new techniques will be discussed.
Fichier principal
Vignette du fichier
S1278321820301645.pdf (719.33 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03034758 , version 1 (21-09-2022)

Licence

Paternité - Pas d'utilisation commerciale

Identifiants

Citer

L. de Marzi, A. Patriarca, N. Scher, J. Thariat, M. Vidal. Exploiting the full potential of proton therapy: An update on the specifics and innovations towards spatial or temporal optimisation of dose delivery. Cancer/Radiothérapie, 2020, 24 (6-7), pp.691-698. ⟨10.1016/j.canrad.2020.06.003⟩. ⟨hal-03034758⟩
23 Consultations
68 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More