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Books Year : 2014

Probabilistic graphical models for genetics, genomics and postgenomics

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Abstract

This is the first book to provide an in-depth description of the mechanisms underlying cutting-edge methods using probabilistic graphical models for genetics, genomics and postgenomics. Its aims are to - promote the use of powerful models through the provision of well documented examples - demystify probabilistic graphical models through a didactic exposition - bridge the gap between different scientific worlds helping scientists to better communicate and contributes to the emergence of new transdisciplinary fields of research - provide precise insights into applications in genetics - give an idea of the huge potential of probabilistic graphical models in genetics, in the broad sense, but also in integrative biology and systems biology Nowadays bioinformaticians and geneticists are faced with myriad high-throughput data usually presenting the characteristics of uncertainty, high dimensionality and large complexity. These data will only allow insights into this wealth of so-called 'omics' data if represented by flexible and scalable models, prior to any further analysis. At the interface between statistics and machine learning, probabilistic graphical models (PGMs) represent a powerful formalism to discover complex networks of relations. These models are also amenable to incorporating a priori biological information. Network reconstruction from gene expression data represents perhaps the most emblematic area of research where PGMs have been successfully applied. However these models have also created renewed interest in genetics in the broad sense, in particular regarding association genetics, causality discovery, prediction of outcomes, detection of copy number variations, and epigenetics. This book provides an overview of the applications of PGMs to genetics, genomics and postgenomics to meet this increased interest. A salient feature of bioinformatics, interdisciplinarity, reaches its limit when an intricate cooperation between domain specialists is requested. Currently, few people are specialists in the design of advanced methods using probabilistic graphical models for postgenomics or genetics. This book deciphers such models so that their perceived difficulty no longer hinders their use and focuses on fifteen illustrations showing the mechanisms behind the models. Probabilistic Graphical Models for Genetics, Genomics and Postgenomics covers six main themes: (1) Gene network inference (2) Causality discovery (3) Association genetics (4) Epigenetics (5) Detection of copy number variations (6) Prediction of outcomes from high-dimensional genomic data. Written by leading international experts, this is a collection of the most advanced work at the crossroads of probabilistic graphical models and genetics, genomics, and postgenomics. The self-contained chapters provide an enlightened account of the pros and cons of applying these powerful techniques. The readership encompasses researchers in Bioinformatics, masters students in Genetics and Bioinformatics ·and engineers designing new bioinformatics solutions.
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Dates and versions

hal-01168658 , version 1 (26-06-2015)

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  • HAL Id : hal-01168658 , version 1

Cite

Christine Sinoquet, Raphaël Mourad (Dir.). Probabilistic graphical models for genetics, genomics and postgenomics. Keith Mansfield. Oxford University Press, 480 p., 2014, 978-0-19-870902-2. ⟨hal-01168658⟩
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