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Article Dans Une Revue Inorganic Chemistry Année : 2022

Bio-Inspired Casein-Derived Antioxidant Peptides Exhibiting a Dual Direct/Indirect Mode of Action

Résumé

Antioxidant compounds are chemicals of primary importance, especially for their applications in nutrition and healthcare, thanks to their abilities to prevent oxidation processes and to limit and/or rebalance the oxidative stress, well-known for its impact on a wide variety of diseases. While several biomolecules are well-known for their antioxidant properties (e.g., ascorbic acid, carotenoids, phenolic derivatives), bio-sourced antioxidants have drawn considerable attention in the last decades, especially bioactive peptides, mainly obtained by the hydrolysis process. Antioxidant peptide sequences are mainly identified a posteriori, thanks to fastidious and time-consuming approaches and techniques, limiting the discovery of new efficient peptides. In this context and taking inspiration from nature, we report herein on a new series of three bio-inspired antioxidant peptides derived from the milk protein casein. These phosphopeptides, designed to chelate the redox-active iron(III) and forming highly soluble complexes up to pH 9, act both as indirect (i.e., inhibition of the metal redox activity) and direct (i.e., radical scavenging) antioxidants
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Dates et versions

hal-03557588 , version 1 (10-11-2022)

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Paternité - Pas d'utilisation commerciale - Pas de modification

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Gizella Csire, François Dupire, Laetitia Canabady-Rochelle, Katalin Selmeczi, Loïc Stefan. Bio-Inspired Casein-Derived Antioxidant Peptides Exhibiting a Dual Direct/Indirect Mode of Action. Inorganic Chemistry, 2022, 61 (4), pp.1941-1948. ⟨10.1021/acs.inorgchem.1c03085⟩. ⟨hal-03557588⟩
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