Thermo- and pH-sensitive aggregation behavior of PDEAm-b-P(L-lysine) double hydrophilic block copolymers in aqueous solution - Laboratoire Charles Coulomb (L2C)
Journal Articles Soft Matter Year : 2013

Thermo- and pH-sensitive aggregation behavior of PDEAm-b-P(L-lysine) double hydrophilic block copolymers in aqueous solution

Abstract

The synthesis and the aggregation behavior of novel well-defined poly(N,N-diethylacrylamide)-b-poly- (L-lysine) (PDEAm-b-PLL) double hydrophilic block copolymers are reported. PDEAm-b-PLL was prepared using an original strategy which consisted of the ring opening polymerization (ROP) of N3- trifluoroacetyl-L-lysine N-carboxyanhydride using terminated-thiol PDEAm as a macroinitiator. After deprotection of the amine group of the L-lysine, pH- and thermo-sensitive poly(N,N-diethylacrylamide)- b-poly(L-lysine) block copolymers were obtained. The structure of the copolymers was characterized by 1H NMR and FT-IR. Then, pH and temperature sensitivities were measured by 1H NMR and UV/Vis spectroscopy. At different pH values and temperatures, poly(L-lysine) and poly(N,N-diethylacrylamide) showed typical behaviors, which led to different types of aggregation in aqueous solution. The influence of both stimuli was carefully investigated by DLS, TEM, and SANS.

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Polymers
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Dates and versions

hal-00769822 , version 1 (03-01-2013)

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Zhang Xuewei, Sophie Monge, Martin In, Olivia Giani, Jean-Jacques Robin. Thermo- and pH-sensitive aggregation behavior of PDEAm-b-P(L-lysine) double hydrophilic block copolymers in aqueous solution. Soft Matter, 2013, 9, pp.1301-1309. ⟨10.1039/c2sm27051j⟩. ⟨hal-00769822⟩
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