Using Discarded Facial Tissues to Monitor and Diagnose Viral Respiratory Infections
Résumé
Molecular biology amplification enables sensitive detection of most respiratory viruses through nasopharyngeal swabbing. We developed an innovative approach to detect viral genomes on used facial tissues. In 2 communities of children, used tissues were collected once weekly for 1 year. Pooled analysis of tissues enabled detection of successive virus circulation in 4 age groups over time and forecasted by several weeks the circulation of influenza in the general population. At the individual level, in a proof-of-concept study of 30 volunteers with influenza-like signs/symptoms, we identified common respiratory viruses. The signals for SARS-CoV-2 obtained in parallel from 15 facial tissues and swab samples were similar and often higher for the tissues (11/15). Individual analysis of tissues offers a noninvasive, sensitive, and affordable alternative to self-sampling without a medical care requirement. Pooled analyses may be used to detect virus spread in specific communities, predict seasonal epidemics, and alert the population to viral infections. © 2023 Centers for Disease Control and Prevention (CDC). All rights reserved.
Mots clés
adenovirus infection
Article
child
clinical article
female
health care facility
human
Human coronavirus 229E
Human coronavirus OC43
Human respiratory syncytial virus
influenza A
influenza A (H1N1)
influenza B
male
nose smear
reproducibility
respiratory syncytial virus infection
respiratory tract infection
reverse transcription polymerase chain reaction
Rhinovirus
sensitivity analysis
Severe acute respiratory syndrome coronavirus 2
skin culture
Varicella zoster virus
virus detection
virus genome
virus transmission
influenza
virus
virus infection
Child
COVID-19
Humans
Influenza, Human
Respiratory Tract Infections
SARS-CoV-2
Virus Diseases
Viruses
Domaines
Sciences du Vivant [q-bio]
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