During inflammation, the body's immune response is characterized by pivotal vascular events between the detection of a pathogen and the presence of tumoral zones. The immune response consists of various stages, including chemical signaling (alert) and diapedesis of WBCs present in the blood, i.e. the passage of WBCs from the blood to the tissues through the endothelial cell wall. If WBCs were homogeneously distributed throughout the blood vessels, the process would not be very efficient. However, it has long been observed that WBCs localize at the periphery of vessels, close to areas of importance, while RBCs cluster in the center. This phenomenon, known as margination, remains poorly understood today, due to a lack of experimental data.