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Article Dans Une Revue Annals of the New York Academy of Sciences Année : 2008

Stress-induced Intercellular Communication Remodeling in the Rat Adrenal Medulla

Résumé

To understand the mechanisms by which a prolonged exposure to stress enhances catecholamine secretion, we examined the effects of 5-day cold exposure on cell-cell communication pathways in the rat adrenal medulla. Upon stress, the neurosecretory tissue undergoes dramatic morphofunctional changes resulting in increased chromaffin cell excitability, upregulation of both chemical transmission at the splanchnic nerve terminal-chromaffin cell synapses and spreading of gap junction-permeant Lucifer yellow between cells. All these changes converge to improve the stimulus-secretion coupling efficiency within the adrenal medulla and subsequently to adapt catecholamine release to a sustained organism demand.
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hal-02484222 , version 1 (19-02-2020)

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Claude Colomer, Chrystel Lafont, Nathalie C. Guérineau. Stress-induced Intercellular Communication Remodeling in the Rat Adrenal Medulla. Annals of the New York Academy of Sciences, 2008, 1148 (1), pp.106-111. ⟨10.1196/annals.1410.040⟩. ⟨hal-02484222⟩
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