Blockade of T-type calcium channels prevents tonic-clonic seizures in a maximal electroshock seizure model
Mots clés
Male
Dose-Response Relationship
Drug
Animals
Mice
Inbred C57BL
Knockout
Disease Models
Animal
Analysis of Variance
Calcium Channels
T-Type/genetics/*metabolism
Anticonvulsant
Benzeneacetamides/*therapeutic use
Brain/drug effects/metabolism
Calcium Channel Blockers/*therapeutic use
Convulsants/toxicity
Electroshock/adverse effects
Evoked Potentials/drug effects/genetics
Extracellular Signal-Regulated MAP Kinases/metabolism
Local Field Potential
Maximal electroshock seizure
Pentylenetetrazole/toxicity
Pyridines/*therapeutic use
Seizures/etiology/pathology/*prevention & control
T-type voltage-gated calcium channels
Tonic-clonic seizure