Highly inert Cu(ii) complexes of C-aryl bifunctional cyclam-picolinates with remarkable Cu-64-labelling and biodistribution - Institut Brestois Santé Agro Matière Accéder directement au contenu
Article Dans Une Revue Chemical Communications Année : 2023

Highly inert Cu(ii) complexes of C-aryl bifunctional cyclam-picolinates with remarkable Cu-64-labelling and biodistribution

Résumé

Cyclam-picolinate chelators were functionalized via click chemistry with an additional carboxyl group for subsequent bioconjugation to antibodies or for the modification of the overall charge of the corresponding Cu-64-radiocomplexes. The C-aryl functionalization strategy developed here preserves the chemical properties of the radiocomplexes whilst deeply enhancing their applications within nuclear medicine.

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Chimie
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Dates et versions

hal-03969219 , version 1 (02-02-2023)

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Citer

Julie Pineau, Luis M P Lima, M Le Roy, Séverine Marionneau-Lambot, Marie Cordier, et al.. Highly inert Cu(ii) complexes of C-aryl bifunctional cyclam-picolinates with remarkable Cu-64-labelling and biodistribution. Chemical Communications, 2023, 59 (7), pp.888-891. ⟨10.1039/d2cc06602e⟩. ⟨hal-03969219⟩
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