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Article Dans Une Revue Journal of Autoimmunity Année : 2021

Rituximab plus belimumab in non-infectious refractory cryoglobulinemia vasculitis: A pilot study

Résumé

Objective: To report the efficacy of rituximab plus belimumab in patients with refractory cryoglobulinemia vasculitis (CV).Methods: Belimumab was administered intravenously at a dose of 10 mg/kg on days 0, 14, 28 and then every month in association with rituximab in 4 patients with refractory CV. Demographic, clinical and laboratory characteristics, treatment modalities and outcomes were recorded.Results: All patients had type II IgM Kappa cryoglobulinemia, which was associated with primary Sjögren syndrome (n = 1), hepatitis C virus infection (n = 1), and essential (n = 2). Main manifestations of CV included purpura (n = 4), arthralgia and peripheral neuropathy (n = 3), and glomerulonephritis and skin ulcers (n = 1). In all cases, CV was refractory and/or relapse following rituximab. Intravenous belimumab infusion along with rituximab resulted in rapid clinical response in the four patients. Osteitis and recurrent urinary tract infections occurred in two patients.Conclusion: Belimumab along with rituximab showed promising results in refractory patients with CV.
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hal-03493570 , version 1 (02-01-2023)

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Paternité - Pas d'utilisation commerciale

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David Saadoun, Amine Ghembaza, Sebastien Riviere, Arsene Mekinian, Jonathan Boutemy, et al.. Rituximab plus belimumab in non-infectious refractory cryoglobulinemia vasculitis: A pilot study. Journal of Autoimmunity, 2021, 116, pp.102577 -. ⟨10.1016/j.jaut.2020.102577⟩. ⟨hal-03493570⟩
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