Deletion of the mu opioid receptor gene in mice reshapes the reward–aversion connectome - Ecole Nationale du Génie de l'Eau et de l'Environnement de Strasbourg Accéder directement au contenu
Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2016

Deletion of the mu opioid receptor gene in mice reshapes the reward–aversion connectome

Résumé

Connectome genetics seeks to uncover how genetic factors shape brain functional connectivity; however, the causal impact of a single gene's activity on whole-brain networks remains unknown. We tested whether the sole targeted deletion of the mu opioid receptor gene (Oprm1) alters the brain connectome in living mice. Hypothesis-free analysis of combined resting-state fMRI diffusion tractography showed pronounced modifications of functional connectivity with only minor changes in structural pathways. Fine-grained resting-state fMRI mapping, graph theory, and intergroup comparison revealed Oprm1-specific hubs and captured a unique Oprm1 gene-to-network signature. Strongest perturbations occurred in connectional patterns of pain/aversion-related nodes, including the mu receptor-enriched habenula node. Our data demonstrate that the main receptor for morphine predominantly shapes the so-called reward/aversion circuitry, with major influence on negative affect centers.

Dates et versions

hal-03653632 , version 1 (27-04-2022)

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Citer

Anna E. Mechling, Tanzil Arefin, Hsu-Lei Lee, Thomas Bienert, Marco Reisert, et al.. Deletion of the mu opioid receptor gene in mice reshapes the reward–aversion connectome. Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (41), pp.11603-11608. ⟨10.1073/pnas.1601640113⟩. ⟨hal-03653632⟩
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