Testing for Trenbolone, an Anabolic Steroid, in Biological Fluids and Head Hair in a Postmortem Case - Ecole Nationale du Génie de l'Eau et de l'Environnement de Strasbourg Accéder directement au contenu
Article Dans Une Revue Journal of Analytical Toxicology Année : 2021

Testing for Trenbolone, an Anabolic Steroid, in Biological Fluids and Head Hair in a Postmortem Case

Résumé

Abstract A 60-year-old man was found dead at home by his wife. The man was known to be a regular trainer in a fitness center and was described as a long-term user of anabolic steroids. The autopsy revealed heart failure with cardiomegaly, visceral congestion, and pulmonary edema. The local prosecutor ordered toxicological analyses but no anatomic pathology test. Initial analyses by the liquid chromatography coupled to quadrupole time-of-flight mass spectrometry system (UPLC-q-TOF-MS) system indicated the presence in femoral blood of trenbolone, an anabolic steroid. Trenbolone was quantified with a liquid chromatography system coupled with a tandem mass spectrometer in various autopsy specimens, including hair. Concentrations of trenbolone were 3.9, 3.2, 231, and lower than 0.5 ng/mL in femoral blood, cardiac blood, bile, and vitreous humor, respectively. Moreover, in head hair, the concentration was 9 pg/mg. The presence of trenbolone in hair can be interpreted as repetitive exposures when compared to the limited literature data. Repetitive misuse of trenbolone can explain advanced heart failure. This paper highlights the importance of testing biological specimens for anabolic steroids in case of heart failure.

Domaines

Toxicologie
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Dates et versions

hal-03625532 , version 1 (30-03-2022)

Identifiants

Citer

Laurie Gheddar, Anne-Laure Pélissier, Jacques Desfeux, Fabrice Niort, Jean-Sébastien Raul, et al.. Testing for Trenbolone, an Anabolic Steroid, in Biological Fluids and Head Hair in a Postmortem Case. Journal of Analytical Toxicology, 2021, 46 (2), ⟨10.1093/jat/bkab091⟩. ⟨hal-03625532⟩
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