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Article Dans Une Revue Physics in Medicine and Biology Année : 2018

MR-ARFI-based method for the quantitative measurement of tissue elasticity: application for monitoring HIFU therapy

Résumé

Monitoring thermal therapies through medical imaging is essential in order to ensure that they are safe, efficient and reliable. In this paper, we propose a new approach, halfway between MR acoustic radiation force imaging (MR-ARFI) and MR elastography (MRE), allowing for the quantitative measurement of the elastic modulus of tissue in a highly localized manner. It relies on the simulation of the MR-ARFI profile, which depends on tissue biomechanical properties, and on the identification of tissue elasticity through the fitting of experimental displacement images measured using rapid MR-ARFI. This method was specifically developed to monitor MR-guided high intensity focused ultrasound (MRgHIFU) therapy. Elasticity changes were followed during HIFU ablations (N  =  6) performed ex vivo in porcine muscle samples, and were compared to temperature changes measured by MR-thermometry. Shear modulus was found to increase consistently and steadily a few seconds after the heating started, and such changes were found to be irreversible. The shear modulus was found to increase from 1.49  ±  0.48 kPa (before ablation) to 3.69  ±  0.93 kPa (after ablation and cooling). Thanks to its ability to perform quantitative elasticity measurements in a highly localized manner around the focal spot, this method proved to be particularly attractive for monitoring HIFU ablations.
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Dates et versions

hal-03541175 , version 1 (24-01-2022)

Identifiants

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Jonathan Vappou, Pierre Bour, Fabrice Marquet, Valery Ozenne, Bruno Quesson. MR-ARFI-based method for the quantitative measurement of tissue elasticity: application for monitoring HIFU therapy. Physics in Medicine and Biology, 2018, 63 (9), pp.095018. ⟨10.1088/1361-6560/aabd0d⟩. ⟨hal-03541175⟩
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