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Journal Articles PNAS Nexus Year : 2024

Impact of the gut microbiome composition on social decision-making

Abstract

There is increasing evidence for the role of the gut microbiome in the regulation of socio-affective behavior in animals and clinical conditions. However, whether and how the composition of the gut microbiome may influence social decision-making in health remains unknown. Here, we tested the causal effects of a 7-week synbiotic (vs. placebo) dietary intervention on altruistic social punishment behavior in an ultimatum game. Results showed that the intervention increased participants’ willingness to forgo a monetary payoff when treated unfairly. This change in social decision-making was related to changes in fasting-state serum levels of the dopamine-precursor tyrosine proposing a potential mechanistic link along the gut–microbiota–brain-behavior axis. These results improve our understanding of the bidirectional role body–brain interactions play in social decision-making and why humans at times act “irrationally” according to standard economic theory.
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hal-04578634 , version 1 (17-05-2024)

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Marie Falkenstein, Marie-Christine Simon, Aakash Mantri, Bernd Weber, Leonie Koban, et al.. Impact of the gut microbiome composition on social decision-making. PNAS Nexus, 2024, 3 (5), ⟨10.1093/pnasnexus/pgae166⟩. ⟨hal-04578634⟩
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