Pretherapeutic Motor Thalamus Resting-State Functional Connectivity with Visual Areas Predicts Tremor Arrest After Thalamotomy for Essential Tremor: Tracing the Cerebello-thalamo-visuo-motor Network - Centre de Résonance Magnétique Biologique et Médicale Accéder directement au contenu
Article Dans Une Revue World Neurosurgery Année : 2018

Pretherapeutic Motor Thalamus Resting-State Functional Connectivity with Visual Areas Predicts Tremor Arrest After Thalamotomy for Essential Tremor: Tracing the Cerebello-thalamo-visuo-motor Network

Constantin Tuleasca
  • Fonction : Auteur
Elena Najdenovska
  • Fonction : Auteur
Jean Régis
Tatiana Witjas
  • Fonction : Auteur
Jérôme Champoudry
  • Fonction : Auteur
Mohamed Faouzi
  • Fonction : Auteur
Jean-Philippe Thiran
  • Fonction : Auteur
Meritxell Bach Cuadra
  • Fonction : Auteur
Marc Levivier
  • Fonction : Auteur
Dimitri van de Ville

Résumé

BACKGROUND: Essential tremor (ET) is a common movement disorder. Resting-state functional magnetic resonance imaging is a noninvasive neuroimaging method acquired in absence of task. OBJECTIVE: Our study aimed to correlate pretherapeutic ventrolateral thalamus functional connectivity (FC) with clinical results 1 year after stereotactic radiosurgical thalamotomy (SRS-T) for drug-resistant ET. Data from 12 healthy control individuals were additionally included. METHODS: Resting state was acquired for 17 consecutive (right-handed) patients, before and 1 year after left unilateral SRS-T. Standard tremor scores were evaluated pretherapeutically and 1 year after SRS-T. Tremor network was investigated using region of interest, left ventrolateral ventral (VLV) cluster, obtained from pretherapeutic diffusion magnetic resonance imaging. Seed-based FC was obtained as correlations between the time courses of the VLV and that of every other voxel. The seed-connectivity maps were obtained pretherapeutically and correlated across all patients with clinical outcome 1 year after SRS-T. One-year magnetic resonance signature volume was always located inside VLV and did not correlate with reported seed-FC measures (P > 0.05). RESULTS: We report statistically significant correlations between pretherapeutic VLV FC with clinical outcome for 1) right visual association area (Brodmann area, BA19) predicting 1 year activities of daily living decrease (Punc~= 0.02); 2) left fusiform gyrus (BA37) predicting 1 year head tremor score improvement (Punc~= 0.04); and 3) posterior cingulate (left BA23, Puncor~= 0.009), lateral temporal cortex (right BA21, Punc~= 0.02) predicting time to tremor arrest. CONCLUSIONS: Our results suggest that pretherapeutic resting-state seed-FC of left VLV predicts tremor arrest after SRS-T for ET. Visual areas are identified as the main regions in this correlation.
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Dates et versions

hal-03590346 , version 1 (27-02-2022)

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Constantin Tuleasca, Elena Najdenovska, Jean Régis, Tatiana Witjas, Nadine Girard, et al.. Pretherapeutic Motor Thalamus Resting-State Functional Connectivity with Visual Areas Predicts Tremor Arrest After Thalamotomy for Essential Tremor: Tracing the Cerebello-thalamo-visuo-motor Network. World Neurosurgery, 2018, 117, pp.e438-e449. ⟨10.1016/j.wneu.2018.06.049⟩. ⟨hal-03590346⟩
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