Exenatide decreases ectopic fat accumulation but have no impact on myocardial function and perfusion in patients with obesity and type 2 diabetes - Centre de Résonance Magnétique Biologique et Médicale Accéder directement au contenu
Communication Dans Un Congrès Année : 2017

Exenatide decreases ectopic fat accumulation but have no impact on myocardial function and perfusion in patients with obesity and type 2 diabetes

Résumé

The objective of the study is to assess the impact of Exenatide on endothelial reactivity, and change in ectopic fat and cardiac function. This study included 44 patients (mean 52 years) randomized to Exenatide or reference treatment. Magnetic resonance imaging was used to assess ectopic fat accumulation, coronary vasoreactivity and cardiac function. 16-weeks of Exenatide treatement resulted in a significant improvement in glycemic control and a significant reduction of both epicardial fat and hepatic steatosis. However, we found no effect of Exenatide on myocardial function. In addition, one-week of exenatide treatment had only a modest effect on vascular reactivity, albeit non-significant.
Fichier non déposé

Dates et versions

hal-01784670 , version 1 (03-05-2018)

Identifiants

  • HAL Id : hal-01784670 , version 1

Citer

Ines Imane Abdesselam, Anne Dutour, Alexis Jacquier, Frank Kober, Patricia Ancel, et al.. Exenatide decreases ectopic fat accumulation but have no impact on myocardial function and perfusion in patients with obesity and type 2 diabetes. 25th Annual Meeting of the International Society for Magnetic Resonance in Medicine, Apr 2017, Honolulu, HI, United States. pp.3250. ⟨hal-01784670⟩
78 Consultations
0 Téléchargements

Partager

Gmail Facebook X LinkedIn More