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Article Dans Une Revue Molecules Année : 2016

Betulin Phosphonates; Synthesis, Structure, and Cytotoxic Activity

Résumé

Betulin derivatives are a widely studied group of compounds of natural origin due to their wide spectrum of biological activities. This paper describes new betulin derivatives, containing a phosphonate group. The allyl-vinyl isomerization and synthesis of acetylenic derivatives have been reported. Structural identification of products as E and Z isomers has been carried out using 1 H-, 13 C-, 31 P-NMR, and crystallographic analysis. The crystal structure in the orthorhombic space group and analysis of crystal packing contacts for 29-diethoxyphosphoryl-28-cyclopropylpropynoyloxy-lup-20E(29)-en-3β-ol 8a are reported. All new compounds were tested in vitro for their antiproliferative activity against human T47D (breast cancer), SNB-19 (glioblastoma), and C32 (melanoma) cell lines.
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Dates et versions

hal-03023562 , version 1 (25-11-2020)

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Elwira Chrobak, Ewa Bębenek, Monika Kadela-Tomanek, Małgorzata Latocha, Christian Jelsch, et al.. Betulin Phosphonates; Synthesis, Structure, and Cytotoxic Activity. Molecules, 2016, 21 (9), pp.1123. ⟨10.3390/molecules21091123⟩. ⟨hal-03023562⟩
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