Synthesis, crystal structure and antibacterial properties of 6-methyl-2-oxo-4-(quinolin-2-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate - CRM2 - Laboratoire de Cristallographie, Résonance Magnétique et Modélisations Accéder directement au contenu
Article Dans Une Revue Journal of Molecular Structure Année : 2020

Synthesis, crystal structure and antibacterial properties of 6-methyl-2-oxo-4-(quinolin-2-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Résumé

The synthesis and investigation of a new biologically active derivative of dihydropyrimidine are reported. The structure of the synthesized compound was investigated by X-ray single crystal diffraction method. In order to understand the molecular interactions, the Hirshfeld surface and contacts enrichment analyses were performed. The crystal packing is mainly stabilized by strong N-H…O hydrogen bonds and aromatic cycle stacking. Among the different types of oxygen atoms, the most electronegative had the highest propensity to form H-bonds. Biological activity of the synthesized compound was studied against E.coli, P. aeruginosa and S. aureus bacteria.
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hal-03004002 , version 1 (13-11-2020)

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A.E. E Huseynzada, C. Jelsch, H.N. N Akhundzada, S. Soudani, C. Ben Nasr, et al.. Synthesis, crystal structure and antibacterial properties of 6-methyl-2-oxo-4-(quinolin-2-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate. Journal of Molecular Structure, 2020, 1219, pp.128581. ⟨10.1016/j.molstruc.2020.128581⟩. ⟨hal-03004002⟩
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