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Article Dans Une Revue Nucleic Acids Research Année : 2010

TFM-Explorer: mining cis-regulatory regions in genomes

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Résumé

DNA-binding transcription factors (TFs) play a central role in transcription regulation, and computational approaches that help in elucidating complex mechanisms governing this basic biological process are of great use. In this perspective, we present the TFM-Explorer web server that is a toolbox to identify putative TF binding sites within a set of upstream regulatory sequences of genes sharing some regulatory mechanisms. TFM-Explorer finds local regions showing overrepresentation of binding sites. Accepted organisms are human, mouse, rat, chicken and drosophila. The server employs a number of features to help users to analyze their data: visualization of selected binding sites on genomic sequences, and selection of cis-regulatory modules. TFM-Explorer is available at http://bioinfo.lifl.fr/TFM.

Dates et versions

hal-00823465 , version 1 (17-05-2013)

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Citer

Tonon Laurie, Hélène Touzet, Jean-Stéphane Varré. TFM-Explorer: mining cis-regulatory regions in genomes. Nucleic Acids Research, 2010, 38 (S2), pp.W286-W292. ⟨10.1093/nar/gkq473⟩. ⟨hal-00823465⟩
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