Combining RAIT and immune-based therapies to overcome resistance in cancer? Combining RAIT and immune-based therapies to overcome resistance in cancer? - Centre de recherche en cancérologie Nantes-Angers Unité Mixte de Recherche 892 Inserm - 6299 CNRS Accéder directement au contenu
Chapitre D'ouvrage Année : 2018

Combining RAIT and immune-based therapies to overcome resistance in cancer? Combining RAIT and immune-based therapies to overcome resistance in cancer?

Résumé

Radiation therapy has long been considered as immunosuppressive; therefore its impact on the immune system and other aspects which could be involved in raising efficient antitumor immune responses has been neglected. However, the recent demonstration of the immunogenic properties of ionizing radiation is rapidly modifying the radiation oncology field, and it also opens new and promising perspectives for the development and improvement of radioimmunotherapy. In this chapter, we first review the immunogenic properties of irradiation before discussing available evidence of the benefits of radiation therapy and immunotherapy combinations in the context of lymphoma.

Domaines

Cancer
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Dates et versions

inserm-02338494 , version 1 (30-10-2019)

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Jean-Baptiste Gorin, Jérémie Ménager, Yannick Guilloux, Jean-François Chatal, Joëlle Gaschet, et al.. Combining RAIT and immune-based therapies to overcome resistance in cancer? Combining RAIT and immune-based therapies to overcome resistance in cancer?. Resistance to Ibritumomab in Lymphoma, 18, pp 119-137, 2018, ⟨10.1007/978-3-319-78238-6_9⟩. ⟨inserm-02338494⟩
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