Consensus nomenclature for CD8+ T cell phenotypes in cancer - Archive ouverte HAL Access content directly
Journal Articles OncoImmunology Year : 2015

Consensus nomenclature for CD8+ T cell phenotypes in cancer

, , , , , , , (1) , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,
1
Lionel Apetoh
  • Function : Author
  • PersonId : 996006
Mark Smyth
  • Function : Author
Charles Drake
  • Function : Author
Pierre Abastado
  • Function : Author
Ron Apte
  • Function : Author
Maha Ayyoub
Jean-Yves Blay
Lisa Butterfield
  • Function : Author
  • PersonId : 899092
Anne Caignard
Chiara Castelli
  • Function : Author
Federica Cavallo
  • Function : Author
Esteban Celis
  • Function : Author
Lieping Chen
  • Function : Author
Mario Colombo
  • Function : Author
Begoña Comin-Anduix
  • Function : Author
Georges Coukos
  • Function : Author
Madhav V Dhodapkar
  • Function : Author
Glenn Dranoff
  • Function : Author
  • PersonId : 924474
Ian Frazer
  • Function : Author
Wolf-Hervé Fridman
  • Function : Author
Dmitry I Gabrilovich
  • Function : Author
Eli Gilboa
  • Function : Author
Sacha Gnjatic
  • Function : Author
Dirk Jäger
  • Function : Author
Pawel Kalinski
  • Function : Author
  • PersonId : 924491
Howard Kaufman
  • Function : Author
  • PersonId : 942526
Rolf Kiessling
  • Function : Author
  • PersonId : 924495
John Kirkwood
  • Function : Author
  • PersonId : 899112
Alexander Knuth
  • Function : Author
Roland Liblau
Michael Lotze
  • Function : Author
  • PersonId : 899116
Enrico Lugli
  • Function : Author
Francesco Marincola
  • Function : Author
  • PersonId : 938464
Ignacio Melero
  • Function : Author
Cornelis Melief
  • Function : Author
Thorsten Mempel
  • Function : Author
Elizabeth A Mittendorf
  • Function : Author
Kunle Odun
  • Function : Author
Willem Overwijk
  • Function : Author
Anna Karolina Palucka
  • Function : Author
Giorgio Parmiani
  • Function : Author
  • PersonId : 924513
Antoni A Ribas
  • Function : Author
Pedro Romero
Robert Schreiber
  • Function : Author
Gerold Schuler
  • Function : Author
Pramod K Srivastava
  • Function : Author
Eric Tartour
Danila Valmori
  • Function : Author
Sjoerd van Der Burg
  • Function : Author
  • PersonId : 924528
Pierre van Der Bruggen
  • Function : Author
Benoît van den Eynde
  • Function : Author
Ena Wang
  • Function : Author
  • PersonId : 899091
Weiping Zou
Theresa L Whiteside
  • Function : Author
Daniel E Speiser
  • Function : Author
Drew Pardoll
  • Function : Author
Nicholas P Restifo
  • Function : Author
Ana Anderson
  • Function : Author

Abstract

Whereas preclinical investigations and clinical studies have established that CD8+ T cells can profoundly affect cancer progression, the underlying mechanisms are still elusive. Challenging the prevalent view that the beneficial effect of CD8+ T cells in cancer is solely attributable to their cytotoxic activity, several reports have indicated that the ability of CD8+ T cells to promote tumor regression is dependent on their cytokine secretion profile and their ability to self-renew. Evidence has also shown that the tumor microenvironment can disarm CD8+ T cell immunity, leading to the emergence of dysfunctional CD8+ T cells. The existence of different types of CD8+ T cells in cancer calls for a more precise definition of the CD8+ T cell immune phenotypes in cancer and the abandonment of the generic terms "pro-tumor" and "antitumor." Based on recent studies investigating the functions of CD8+ T cells in cancer, we here propose some guidelines to precisely define the functional states of CD8+ T cells in cancer.

Dates and versions

inserm-01817717 , version 1 (18-06-2018)

Identifiers

Cite

Lionel Apetoh, Mark Smyth, Charles Drake, Pierre Abastado, Ron Apte, et al.. Consensus nomenclature for CD8+ T cell phenotypes in cancer. OncoImmunology, 2015, 4 (4), ⟨10.1080/2162402X.2014.998538⟩. ⟨inserm-01817717⟩
108 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More