A new protoparvovirus in human fecal samples and cutaneous T cell lymphomas (mycosis fungoides) - Archive ouverte HAL Access content directly
Journal Articles Virology Year : 2016

A new protoparvovirus in human fecal samples and cutaneous T cell lymphomas (mycosis fungoides)

(1, 2) , (3, 4) , (5, 2) , (2, 1) , (6) , (2, 1) , (2, 1) , (2, 7) , (3, 4) , (8, 9) , (10) , (11, 12) , (13) , (2, 1)
1
2
3
4
5
6
7
8
9
10
11
12
13

Abstract

We genetically characterized seven nearly complete genomes in the protoparvovirus genus from the feces of children with diarrhea. The viruses, provisionally named cutaviruses (CutaV), varied by 1–6% nucleotides and shared $ 76% and $ 82% amino acid identity with the NS1 and VP1 of human bufa-viruses, their closest relatives. Using PCR, cutavirus DNA was found in 1.6% (4/245) and 1% (1/100) of diarrhea samples from Brazil and Botswana respectively. In silico analysis of pre-existing metagenomics datasets then revealed closely related parvovirus genomes in skin biopsies from patients with epi-dermotropic cutaneous T-cell lymphoma (CTCL or mycosis fungoides). PCR of skin biopsies yielded cu-tavirus DNA in 4/17 CTCL, 0/10 skin carcinoma, and 0/21 normal or noncancerous skin biopsies. In situ hybridization of CTCL skin biopsies detected viral genome within rare individual cells in regions of neoplastic infiltrations. The influence of cutavirus infection on human enteric functions and possible oncolytic role in CTCL progression remain to be determined.
Embargoed file
Embargoed file
Ne sera jamais visible

Dates and versions

inserm-01408880 , version 1 (05-12-2016)

Identifiers

Cite

Tung A Phan, Brigitte Dreno, Antonio A Charlys da Costa, Linlin A Li, Patricia Orlandi, et al.. A new protoparvovirus in human fecal samples and cutaneous T cell lymphomas (mycosis fungoides). Virology, 2016, 496, pp.299 - 305. ⟨10.1016/j.virol.2016.06.013⟩. ⟨inserm-01408880⟩
152 View
2 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More