Pleural Effusions from Patients with Mesothelioma Induce Recruitment of Monocytes and Their Differentiation into M2 Macrophages - Centre de recherche en cancérologie Nantes-Angers Unité Mixte de Recherche 892 Inserm - 6299 CNRS Accéder directement au contenu
Article Dans Une Revue Journal of Thoracic Oncology Année : 2016

Pleural Effusions from Patients with Mesothelioma Induce Recruitment of Monocytes and Their Differentiation into M2 Macrophages

Résumé

Introduction: Mesothelioma is a rare and aggressive cancer related to asbestos exposure. We recently showed that pleural effusions (PEs) from patients with mesothelioma contain high levels of the CC motif chemokine ligand 2 (CCL2) inflammatory chemokine. In the present work, we studied the effect of CCL2 contained in mesothelioma samples , particularly on monocyte recruitment. Then, we studied the fate of these monocytes in malignant pleural mesotheli-oma (MPM) PEs and their impact on tumor cells' properties.

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Cancer
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Dates et versions

inserm-01386814 , version 1 (24-10-2016)

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Anne-Laure Chéné, Sènan D’almeida, Thibaut Blondy, Julie Tabiasco, Sophie Deshayes, et al.. Pleural Effusions from Patients with Mesothelioma Induce Recruitment of Monocytes and Their Differentiation into M2 Macrophages. Journal of Thoracic Oncology, 2016, 11 (10), pp.1765 - 1773. ⟨10.1016/j.jtho.2016.06.022⟩. ⟨inserm-01386814⟩
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