Targeting and killing glioblastoma with monoclonal antibody to O-acetyl GD2 ganglioside
Résumé
There are still unmet medical needs in the treatment of glioblastoma, the
most common and the most aggressive glioma of all brain tumors. Here, we found
that O-acetyl GD2 is expressed in surgically resected human glioblastoma tissue.
In addition, we demonstrated that 8B6 monoclonal antibody specific for O-acetylat
GD2 could effectively inhibit glioblastoma cell proliferation in vitro and in vivo. Taken
together, these results indicate that O-acetylated GD2 represents a novel antigen for
immunotherapeutic-based treatment of high-grade gliomas.
Domaines
CancerOrigine | Fichiers produits par l'(les) auteur(s) |
---|
Loading...