Stereotactic body radiation therapy for abdominal oligometastases: a biological and clinical review. - Archive ouverte HAL Access content directly
Journal Articles Radiation Oncology Year : 2012

Stereotactic body radiation therapy for abdominal oligometastases: a biological and clinical review.

(1) , (1, 2) , (2) , (1) , (1)
1
2

Abstract

ABSTRACT: Advances in imaging and biological targeting have led to the development of stereotactic body radiation therapy (SBRT) as an alternative treatment of extracranial oligometastases. New radiobiological concepts, such as ceramide-induced endothelial apoptosis after hypofractionated high-dose SBRT, and the identification of patients with oligometastatic disease by microRNA expression may yet lead to further developments. Key factors in SBRT are delivery of a high dose per fraction, proper patient positioning, target localisation, and management of breathing-related motion. Our review addresses the radiation doses and schedules used to treat liver, abdominal lymph node (LN) and adrenal gland oligometastases and treatment outcomes. Reported local control (LC) rates for liver and abdominal LN oligometastases are high (median 2-year actuarial LC: 61 -100% for liver oligometastases; 4-year actuarial LC: 68% in a study of abdominal LN oligometastases). Early toxicity is low-to-moderate; late adverse effects are rare. SBRT of adrenal gland oligometastases shows promising results in the case of isolated lesions. In conclusion, properly conducted SBRT procedures are a safe and effective treatment option for abdominal oligometastases.
Fichier principal
Vignette du fichier
1748-717X-7-126.pdf (220.85 Ko) Télécharger le fichier
Vignette du fichier
1748-717X-7-126.xml (104.48 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Format : Other
Loading...

Dates and versions

inserm-00747674 , version 1 (31-10-2012)

Identifiers

Cite

Mohammed Yahia Almaghrabi, Stéphane Supiot, Francois Paris, Marc-André Mahé, Emmanuel Rio. Stereotactic body radiation therapy for abdominal oligometastases: a biological and clinical review.. Radiation Oncology, 2012, 7 (1), pp.126. ⟨10.1186/1748-717X-7-126⟩. ⟨inserm-00747674⟩
90 View
527 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More