Treg depletion followed by intracerebral CpG-ODN injection induce brain tumor rejection - Archive ouverte HAL Access content directly
Journal Articles Journal of Neuroimmunology Year : 2014

Treg depletion followed by intracerebral CpG-ODN injection induce brain tumor rejection

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Ulrich Jarry
  • Function : Author
Sabrina Donnou
  • Function : Author
Marie Vincent
  • Function : Author
Laurent Pineau
  • Function : Author
Isabelle Frémaux
  • Function : Author

Abstract

Using brain lymphoma model, we demonstrate that immunotherapy combining Treg depletion (using anti-CD25 mAb PC61) followed by intracranial CpG-ODN administration induced tumor rejection in all treated mice and led to the establishment of a memory antitumor immune response in 60% of them. This protective effect was associated with a recruitment of NK cells and, to a lesser extent, of dendritic cells, B cells and T lymphocytes. NK cell depletion abolished the protective effect of the treatment, confirming a major role of NK cells in brain tumor elimination. Each treatment used alone failed to protect brain tumor bearing mice, revealing the therapeutic benefit of combining Treg depletion and local CpG-ODN injection.

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hal-03389734 , version 1 (21-10-2021)

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Ulrich Jarry, Sabrina Donnou, Marie Vincent, Pascale Jeannin, Laurent Pineau, et al.. Treg depletion followed by intracerebral CpG-ODN injection induce brain tumor rejection. Journal of Neuroimmunology, 2014, 267 (1–2), pp.35 - 42. ⟨10.1016/j.jneuroim.2013.12.005⟩. ⟨hal-03389734⟩
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