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Journal Articles Epidemics Year : 2013

Infectivity of GI and GII noroviruses established from oyster related outbreaks

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Abstract

Noroviruses (NoVs) are the major cause of acute epidemic gastroenteritis in industrialized countries. Outbreak strains are predominantly genogroup II (GII) NoV, but genogroup I (GI) strains are regularly found in oyster related outbreaks. The prototype Norwalk virus (GI), has been shown to have high infectivity in a human challenge study. Whether other NoVs are equally infectious via natural exposure remains to be established. Human susceptibility to NoV is partly determined by the secretor status (Se+/-). Data from five published oyster related outbreaks were analyzed in a Bayesian framework. Infectivity estimates where high and consistent with NV(GI) infectivity, for both GII and GI strains. The median and CI95 probability of infection and illness, in Se+ subjects, associated with exposure to a mean of one single NoV genome copy were around 0.29[0.015–0.61] for GI and 0.4[0.04–0.61] for GII, and for illness 0.13 [0.007–0.39] for GI and 0.18 [0.017–0.42] for GII. Se- subjects were strongly protected against infection. The high infectivity estimates for Norwalk virus GI and GII, makes NoVs critical target for food safety regulations.

Dates and versions

hal-02646936 , version 1 (29-05-2020)

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Anne Thébault, Peter Teunis, Jacques Le Pendu, Soizick Françoise Le Guyader, Jean-Baptiste Denis. Infectivity of GI and GII noroviruses established from oyster related outbreaks. Epidemics, 2013, 5 (2), pp.98-110. ⟨10.1016/j.epidem.2012.12.004⟩. ⟨hal-02646936⟩
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