Effect on comfort of administering bubble-humidified or dry oxygen: the Oxyrea non-inferiority randomized study - Archive ouverte HAL Access content directly
Journal Articles Annals of Intensive Care Year : 2018

Effect on comfort of administering bubble-humidified or dry oxygen: the Oxyrea non-inferiority randomized study

, (1, 2) , (3) , , , , , , , , , (4) ,
1
2
3
4
Laurent Poiroux
  • Function : Author
  • PersonId : 1070114
Cyril Le Roy
  • Function : Author
Karine Colonval
  • Function : Author
Carole Agasse
  • Function : Author
Vanessa Zinzoni
  • Function : Author
Vanessa Hodebert
  • Function : Author
Alexandre Cambonie
  • Function : Author
Josselin Saletes
  • Function : Author
Irma Bourgeon
  • Function : Author
Alain Mercat
  • Function : Author

Abstract

BACKGROUND: The clinical interest of using bubble humidification of oxygen remains controversial. This study was designed to further explore whether delivering dry oxygen instead of bubble-moistened oxygen had an impact on discomfort of ICU patients.

METHODS: This randomized multicenter non-inferiority open trial included patients admitted in intensive care unit and receiving oxygen. Any patient receiving non-humidified oxygen (between 0 and 15 L/min) for less than 2 h could participate in the study. Randomization was stratified based on the flow rate at inclusion (less or more than 4 L/min). Discomfort was assessed 6-8 and 24 h after inclusion using a dedicated 15-item scale (quoted from 0 to 150).

RESULTS: Three hundred and fifty-four ICU patients receiving non-humidified oxygen were randomized either in the humidified (HO) (n = 172), using bubble humidifiers, or in the non-humidified (NHO) (n = 182) arms. In modified intention-to-treat analysis at H6-H8, the 15-item score was 26.6 ± 19.4 and 29.8 ± 23.4 in the HO and NHO groups, respectively. The absolute difference between scores in both groups was 3.2 [90% CI 0.0; + 6.5] for a non-inferiority margin of 5.3, meaning that the non-inferiority analysis was not conclusive. This was also true for the subgroups of patients receiving either less or more than 4 L/min of oxygen. At H24, using NHO was not inferior compared to HO in the general population and in the subgroup of patients receiving 4 L/min or less of oxygen. However, for patients receiving more than 4 L/min, a post hoc superiority analysis suggested that patients receiving dry oxygen were less comfortable.

CONCLUSIONS: Oxygen therapy-related discomfort was low. Dry oxygen could not be demonstrated as non-inferior compared to bubble-moistened oxygen after 6-8 h of oxygen administration. At 24 h, dry oxygen was non-inferior compared to bubble-humidified oxygen for flows below 4 L/min.

Dates and versions

hal-02616867 , version 1 (25-05-2020)

Identifiers

Cite

Laurent Poiroux, Lise Piquilloud, Valérie Seegers, Cyril Le Roy, Karine Colonval, et al.. Effect on comfort of administering bubble-humidified or dry oxygen: the Oxyrea non-inferiority randomized study. Annals of Intensive Care, 2018, 8, pp.126. ⟨10.1186/s13613-018-0472-9⟩. ⟨hal-02616867⟩
28 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More