Ovarian and peritoneal psammocarcinoma: Results of a multicenter study on 25 patients
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Jean-Baptiste Delhorme
- Function : Author
- PersonId : 1041911
Jordan Ohayon
- Function : Author
Sébastien Gouy
- Function : Author
- PersonId : 769702
- IdRef : 081690576
Philippe Morice
- Function : Author
- PersonId : 759700
- ORCID : 0000-0003-0579-9993
- IdRef : 057561621
Julio Abba
- Function : Author
Gisèle Balagué
- Function : Author
Vincent Barrau
- Function : Author
Houda Ben Rejeb
- Function : Author
Isabelle Berton-Rigaud
- Function : Author
Isabelle Bonnefoy
- Function : Author
Dominique Bouzard
- Function : Author
Anne Chevallier
- Function : Author
Anthony Dohan
- Function : Author
- PersonId : 770605
- ORCID : 0000-0002-8732-5603
Julien Dubreuil
- Function : Author
Juliette Fontaine
- Function : Author
Laure Fournier
- Function : Author
- PersonId : 740491
- IdHAL : laure-fournier
- ORCID : 0000-0002-1878-0290
- IdRef : 107973731
Delphine Geffroy
- Function : Author
Laurent Ghouti
- Function : Author
Aymeric Guibal
- Function : Author
Frédéric Guyon
- Function : Author
Christine Hoeffel
- Function : Author
- PersonId : 178717
- IdHAL : christine-hoeffel
- ORCID : 0000-0002-2551-3545
- IdRef : 123786770
Peggy Jourdan-Enfer
- Function : Author
Agnès Leroux-Broussier
- Function : Author
Yoann Lherm
- Function : Author
Emilie Mathiotte
- Function : Author
Eliane Mery
- Function : Author
- PersonId : 763697
- ORCID : 0000-0002-0354-4519
Olivier Pellet
- Function : Author
Marc Pocard
- Function : Author
- PersonId : 184223
- IdHAL : marc-pocard
- ORCID : 0000-0002-4793-0008
- IdRef : 151541809
Patrick Rat
- Function : Author
- PersonId : 919115
Pascal Rousset
- Function : Author
- PersonId : 777021
- ORCID : 0000-0001-6956-2800
- IdRef : 172651115
Martine Serrano
- Function : Author
Vincent Servois
- Function : Author
- PersonId : 792533
- ORCID : 0000-0002-8378-8432
Olivia Sgabura
- Function : Author
Véronique Verriele-Beurrier
- Function : Author
Laurent Villeneuve
- Function : Author
- PersonId : 764853
- ORCID : 0000-0002-8713-7821
- IdRef : 225871777
Abstract
Purpose: Psammocarcinoma (PK) is a rare disease of unknown origin. We aimed to report the characteristics, management and survival of patients operated on for PK within the French Network for Rare Peritoneal Malignancies (RENAPE) expert centers.
Patients and methods: All consecutive cases of PK operated within all 26 RENAPE centers between 1997 and 2018 were retrospectively analyzed.
Results: Twenty-five patients were identified. The median age was 53 years [range 17–78]. None of the patients had extra peritoneal metastases at diagnosis. A median of 6 cycles of carboplatin-based systemic chemotherapy was delivered in 52% preoperatively (n = 13) and 56% postoperatively (n = 14); associated with placlitaxel for 12 patients. All patients were operated on. The median PCI was 23 [0–33]. Eighty-four percent had a complete cytoreductive surgery through digestive (n = 7), spleen (n = 3), pancreas (n = 1) resections and/or multiple peritonectomies (n = 11). Five patients (20%) had intraperitoneal chemotherapy. Morbidity (Dindo-Clavien ≥3) was 12%. No postoperative death occurred. After a median follow-up of 42 months (range [2–194]), the median overall (OS) and progression-free (DFS) survival times were respectively 128 months and 31 months. Eighteen patients recurred (72%), mainly in the peritoneum (n = 16). Four of them (22%) were reoperated. The 5 and 10-year DFS rates were both 20.3%. The 5 and 10-year OS rates were 62% and 51.7%, respectively. A complete cytoreductive surgery was associated with a better OS and DFS in a univariate analysis.
Conclusion: Complete cytoreductive surgery is the cornerstone of the PK's management as a primary treatment. Recurrence remains common and new adjuvant strategies seem needed.