The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation - Archive ouverte HAL Access content directly
Journal Articles Bone Marrow Transplantation Year : 2018

The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation

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Stefan O. Ciurea
  • Function : Author
Kai Cao
  • Function : Author
Marcelo Fernadez-Vina
  • Function : Author
Piyanuch Kongtim
  • Function : Author
Monzr Al Malki
  • Function : Author
Ephraim Fuchs
  • Function : Author
Leo Luznik
  • Function : Author
Xiao-Jun Huang
Massimo Martelli
  • Function : Author
Rupert Handgretinger
  • Function : Author
Denis-Claude Roy
  • Function : Author
Paul O'Donnell
  • Function : Author
Asad Bashey
  • Function : Author
Hillard M. Lazarus
  • Function : Author
Karen Ballen
  • Function : Author
Bipin N. Savani
  • Function : Author

Abstract

Haploidentical donors are now increasingly considered for transplantation in the absence of HLA-matched donors or when an urgent transplant is needed. Donor-specific anti-HLA antibodies (DSA) have been recently recognized as an important barrier against successful engraftment of donor cells, which can affect transplant survival. DSA appear more prevalent in this type of transplant due to higher likelihood of alloimmunization of multiparous females against offspring's HLA antigens, and the degree of mismatch. Here we summarize the evidence for the role of DSA in the development of primary graft failure in haploidentical transplantation and provide consensus recommendations from the European Society for Blood and Marrow Transplant Group on testing, monitoring, and treatment of patients with DSA receiving haploidentical hematopoietic progenitor cell transplantation.

Dates and versions

hal-02143577 , version 1 (29-05-2019)

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Stefan O. Ciurea, Kai Cao, Marcelo Fernadez-Vina, Piyanuch Kongtim, Monzr Al Malki, et al.. The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation. Bone Marrow Transplantation, 2018, 53 (5), pp.521-534. ⟨10.1038/s41409-017-0062-8⟩. ⟨hal-02143577⟩
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