Phytochemicals Isolated from Leaves of Chromolaena odorata: Impact on Viability and Clonogenicity of Cancer Cell Lines - Archive ouverte HAL Access content directly
Journal Articles Phytotherapy Research Year : 2013

Phytochemicals Isolated from Leaves of Chromolaena odorata: Impact on Viability and Clonogenicity of Cancer Cell Lines

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Abstract

The leaves of Chromolaena odorata (Asteraceae) are exploited extensively in West and Central African ethnopharmacy for the treatment of a wide range of conditions, despite this being a non-native species established in the last 50years. With the objective of seeking bioactive principles, the nonvolatile compounds, an ethanolic (80% v/v) extract was made and fractionated. From the hexane-soluble fraction, three compounds were isolated. Two of these, 5-hydroxy-7,4-dimethoxyflavanone and 2-hydroxy-4,4,5,6-tetramethoxychalcone, have previously been identified in C.odorata leaves. The third was fully characterised spectroscopically and found to be 1,6-dimethyl-4-(1-methylethyl)naphthalene (cadalene), not previously isolated from the Asteraceae. All three compounds were tested for their cytotoxicity and anticancer properties. 2-Hydroxy-4,4,5,6-tetramethoxychalcone was found to be both cytotoxic and anticlonogenic at 20 mu m in cell lines Cal51, MCF7 and MDAMB-468, and to act synergistically with the Bcl2 inhibitor ABT737 to enhance apoptosis in Cal51 breast cancer cells. Copyright (c) 2012 John Wiley & Sons, Ltd.

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hal-02142463 , version 1 (28-05-2019)

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Prevost Bi-Koffi Kouame, Camille Jacques, Gustave Bedi, Virginie Silvestre, Denis Loquet, et al.. Phytochemicals Isolated from Leaves of Chromolaena odorata: Impact on Viability and Clonogenicity of Cancer Cell Lines. Phytotherapy Research, 2013, 27 (6), pp.835-840. ⟨10.1002/ptr.4787⟩. ⟨hal-02142463⟩
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