Superacid and thiol-ene reactions for access to psammaplin analogues with HDAC inhibition activities - Archive ouverte HAL Access content directly
Journal Articles Tetrahedron Year : 2014

Superacid and thiol-ene reactions for access to psammaplin analogues with HDAC inhibition activities

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Abstract

An innovative synthesis of psammaplin-like structure is proposed based on original methodologies using superacid, microwaves, and S-ene chemistry. The new compounds were evaluated as histone deacetylase inhibitors. The results highlight important considerations when using disulfide prodrugs activated under reductive/oxidative conditions that must be carefully selected depending on tumor cell types
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hal-01314516 , version 1 (11-05-2016)

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Fatima El Bahhaj, Jerome Desire, Christophe Blanquart, Nadine Martinet, Vincent Zwick, et al.. Superacid and thiol-ene reactions for access to psammaplin analogues with HDAC inhibition activities . Tetrahedron, 2014, 70 (51 ), pp.9702-9708 ⟨10.1016/j.tet.2014.10.053⟩. ⟨hal-01314516⟩
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