Superacid and thiol-ene reactions for access to psammaplin analogues with HDAC inhibition activities - Centre de recherche en cancérologie Nantes-Angers Unité Mixte de Recherche 892 Inserm - 6299 CNRS Access content directly
Journal Articles Tetrahedron Year : 2014

Superacid and thiol-ene reactions for access to psammaplin analogues with HDAC inhibition activities

Abstract

An innovative synthesis of psammaplin-like structure is proposed based on original methodologies using superacid, microwaves, and S-ene chemistry. The new compounds were evaluated as histone deacetylase inhibitors. The results highlight important considerations when using disulfide prodrugs activated under reductive/oxidative conditions that must be carefully selected depending on tumor cell types
No file

Dates and versions

hal-01314516 , version 1 (11-05-2016)

Identifiers

Cite

Fatima El Bahhaj, Jerome Desire, Christophe Blanquart, Nadine Martinet, Vincent Zwick, et al.. Superacid and thiol-ene reactions for access to psammaplin analogues with HDAC inhibition activities . Tetrahedron, 2014, 70 (51 ), pp.9702-9708 ⟨10.1016/j.tet.2014.10.053⟩. ⟨hal-01314516⟩
55 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More