Chromosomal abnormalities are major prognostic factors in elderly patients with multiple myeloma: the intergroupe francophone du myélome experience - Archive ouverte HAL Access content directly
Journal Articles Journal of Clinical Oncology Year : 2013

Chromosomal abnormalities are major prognostic factors in elderly patients with multiple myeloma: the intergroupe francophone du myélome experience

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Philippe Rodon
  • Function : Author
Bruno Royer
  • Function : Author
Mamoun Dib
  • Function : Author
Denis Caillot
  • Function : Author
Marc Wetterwald
  • Function : Author
Brigitte Pegourie
  • Function : Author
Anne-Marie Stoppa
  • Function : Author
Jean-Gabriel Fuzibet
  • Function : Author
Xavier Delbrel
  • Function : Author
  • PersonId : 955441
Thierry Lamy
  • Function : Author
Laurent Garderet
Olivier Allangba
  • Function : Author
Francois Lifermann
  • Function : Author
  • PersonId : 955440
Bruno Anglaret
  • Function : Author
Philippe Moreau

Abstract

PURPOSE: Chromosomal abnormalities, especially t(4;14) and del(17p), are major prognostic factors in patients with multiple myeloma (MM). However, this has been especially demonstrated in patients age \textless 66 years treated with intensive approaches. The goal of this study was to address this issue in elderly patients treated with conventional-dose chemotherapy. PATIENTS AND METHODS: To answer this important question, we retrospectively analyzed a series of 1,890 patients (median age, 72 years; range, 66 to 94 years), including 1,095 with updated data on treatment modalities and survival. RESULTS: This large study first showed that the incidence of t(4;14) was not uniform over age, with a marked decrease in the oldest patients. Second, it showed that both t(4;14) and del(17p) retained their prognostic value in elderly patients treated with melphalan and prednisone-based chemotherapy. CONCLUSION: t(4;14) and del(17p) are major prognostic factors in elderly patients with MM, both for progression-free and overall survival, indicating that these two abnormalities should be investigated at diagnosis of MM, regardless of age.

Dates and versions

hal-01064339 , version 1 (16-09-2014)

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Hervé Avet-Loiseau, Cyrille Hulin, Loic Campion, Philippe Rodon, Gerald Marit, et al.. Chromosomal abnormalities are major prognostic factors in elderly patients with multiple myeloma: the intergroupe francophone du myélome experience. Journal of Clinical Oncology, 2013, 31 (22), pp.2806--2809. ⟨10.1200/JCO.2012.46.2598⟩. ⟨hal-01064339⟩
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