Double umbilical cord blood transplantation for hematological malignancies: a long- term analysis from the SFGM-TC registry. - Archive ouverte HAL Access content directly
Journal Articles Experimental Hematology Year : 2013

Double umbilical cord blood transplantation for hematological malignancies: a long- term analysis from the SFGM-TC registry.

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Hélène Labussière Wallet
  • Function : Author
Mohamad Sobh
  • Function : Author
Sabine Fürst
  • Function : Author
Eric Deconinck
Anne Sirvent
  • Function : Author
Marc Renaud
Nathalie Dhedin
  • Function : Author
Sébastien Maury
  • Function : Author
Agnès Buzyn
  • Function : Author
Gérard Michel
  • Function : Author
Jean-Yves Cahn
  • Function : Author
Ibrahim Yacoub-Agha
  • Function : Author
Evelyne Marry
  • Function : Author
Marie-Lorraine Balère
  • Function : Author
Vanderson Rocha
  • Function : Author
Gérard Socié
Didier Blaise
Noël Milpied
  • Function : Author

Abstract

: Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for many hematological malignancies for which umbilical cord blood (UCB) represents an alternative source of HSC. In order to overcome the low cellularity of one UCB unit, double UCBT (dUCBT) has been developed in adults. We have analyzed the outcome of 136 patients who underwent dUCBT reported to the SFGM-TC registry between 2005 and 2007. Forty-six patients received myeloablative and 90 reduced intensity conditioning regimens. There were 84 leukemias, 17 NHL, 11 myelomas and 24 other hematological malignancies. At transplantation, 40 (29%) patients were in CR1. At day 60 after transplantation, the cumulative incidence of neutrophil recovery was 91%. We observed one UCB unit domination in 88% of cases. The cumulative incidence of day 100 aGVHD, cGVHD, TRM and relapse at 2 years were 36%, 23%, 27% and 28% respectively. After a median follow-up of 49.5 months, the 3 years probabilities of overall and progression-free survival were 41% and 35% respectively with a significant OS advantage when male cord engrafted male recipients. We obtained a long term plateau among patients in CR1 which makes dUCBT a promising treatment strategy for these patients.

Dates and versions

hal-00849674 , version 1 (31-07-2013)

Identifiers

Cite

Hélène Labussière Wallet, Mohamad Sobh, Stéphane Morisset, Marie Robin, Nathalie Fegueux, et al.. Double umbilical cord blood transplantation for hematological malignancies: a long- term analysis from the SFGM-TC registry.. Experimental Hematology, 2013, 41 (11), pp.924-933. ⟨10.1016/j.exphem.2013.05.297⟩. ⟨hal-00849674⟩
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