Reduced-intensity conditioning before allogeneic hematopoietic stem cell transplantation in patients over 60 years: a report from the SFGM-TC. - Centre de recherche en cancérologie Nantes-Angers Unité Mixte de Recherche 892 Inserm - 6299 CNRS Accéder directement au contenu
Article Dans Une Revue Biology of Blood and Marrow Transplantation Année : 2012

Reduced-intensity conditioning before allogeneic hematopoietic stem cell transplantation in patients over 60 years: a report from the SFGM-TC.

Patrice Chevallier
Richard M Szydlo
  • Fonction : Auteur
Didier Blaise
Madalina Uzunov
  • Fonction : Auteur
Simona Lapusan
  • Fonction : Auteur
Jean-Yves Cahn
  • Fonction : Auteur
Gerard Socié
Ibrahim Yakoub-Agha
Sylvie Francois
  • Fonction : Auteur
Sébastien Maury
  • Fonction : Auteur
Agnes Buzyn
  • Fonction : Auteur
Nathalie Contentin
  • Fonction : Auteur

Résumé

This retrospective multicenter report assessed the outcome of 600 patients with hematologic diseases older than 60 years who received reduced-intensity conditioning (RIC) allogeneic hematopoietic stem cell transplantation (allo-HSCT), with the specific aim to compare outcomes of patients between 60 and 65 years old (N = 493) with those older than 65 years (N = 107). Except for donor age, there were no significant differences between the groups regarding patients, diseases, and allo-HSCT characteristics. At time of RIC allo-HSCT, 276 patients (46%) were in complete remission. With a median follow-up of 22.8 and 23.7 months in the younger and the older groups, respectively, 2-year relapse, nonrelapse mortality, disease-free survival, and overall survival rates were similar in both groups (29.6% vs. 20.4%; 29.9% vs. 34.6%; 40.6% vs. 46.7%; 49.2% vs. 50.2%, respectively; P = NS for all comparisons). In a Cox multivariate analysis, after adjustment for disease and transplant factors, age per se was not an adverse factor for survival (relative risk = 1.08; 95% confidence interval, 0.81-1.44, P = .62). We conclude that in selected patients, RIC allo-HSCT could be offered to patients over 65 years old.

Domaines

Cancer

Dates et versions

hal-00849660 , version 1 (31-07-2013)

Identifiants

Citer

Patrice Chevallier, Richard M Szydlo, Didier Blaise, Reza Tabrizi, Mauricette Michallet, et al.. Reduced-intensity conditioning before allogeneic hematopoietic stem cell transplantation in patients over 60 years: a report from the SFGM-TC.. Biology of Blood and Marrow Transplantation, 2012, 18 (2), pp.289-94. ⟨10.1016/j.bbmt.2011.07.013⟩. ⟨hal-00849660⟩
1326 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More