NPY promotes chemokinesis and neurogenesis in the rat subventricular zone. - Centre de recherche en cancérologie Nantes-Angers Unité Mixte de Recherche 892 Inserm - 6299 CNRS Accéder directement au contenu
Article Dans Une Revue Journal of Neurochemistry Année : 2011

NPY promotes chemokinesis and neurogenesis in the rat subventricular zone.

Résumé

J. Neurochem. (2011) 116, 1018-1027. ABSTRACT: The subventricular zone (SVZ) is a major reservoir for stem cells in the adult mammalian brain. Neural stem cells supply the olfactory bulb with new interneurons and provide cells that migrate towards lesioned brain areas. Neuropeptide Y (NPY), one of the most abundant neuropeptides in the brain, was previously shown to induce neuroproliferation on mice SVZ cells. In the present study, performed in rats, we demonstrate the endogenous synthesis of NPY by cells in the SVZ that suggests that NPY could act as an autocrine/paracrine factor within the SVZ area. We observed that NPY promotes SVZ cell proliferation as previously reported in mice, but does not affect self-renewal of SVZ stem cells. Additionally, this study provides the first direct evidence of a chemokinetic activity of NPY on SVZ cells. Using pharmacological approaches, we demonstrate that both the mitogenic and chemokinetic properties of NPY involve Y1 receptor-mediated activation of the ERK1/2 MAP kinase pathway. Altogether, our data establish that NPY through Y1 receptors activation controls chemokinetic activity and, as for mice, is a major neuroproliferative regulator of rat SVZ cells.

Domaines

Neurobiologie

Dates et versions

hal-00582387 , version 1 (01-04-2011)

Identifiants

Citer

Nathalie Thiriet, Fabienne Agasse, Camille Nicoleau, Christelle Guégan, François M. Vallette, et al.. NPY promotes chemokinesis and neurogenesis in the rat subventricular zone.. Journal of Neurochemistry, 2011, 116 (6), pp.1018-27. ⟨10.1111/j.1471-4159.2010.07154.x⟩. ⟨hal-00582387⟩
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