A Kunjin Replicon Virus-like Particle Vaccine Provides Protection Against Ebola Virus Infection in Nonhuman Primates - CIRI - Bases moléculaires de la pathogénicité virale Accéder directement au contenu
Article Dans Une Revue Journal of Infectious Diseases Année : 2015

A Kunjin Replicon Virus-like Particle Vaccine Provides Protection Against Ebola Virus Infection in Nonhuman Primates

Résumé

The current unprecedented outbreak of Ebola virus (EBOV) disease in West Africa has demonstrated the urgent need for a vaccine. Here, we describe the evaluation of an EBOV vaccine candidate based on Kunjin replicon virus-like particles (KUN VLPs) encoding EBOV glycoprotein with a D637L mutation (GP/D637L) in nonhuman primates. Four African green monkeys (Cercopithecus aethiops) were injected subcutaneously with a dose of 10(9) KUN VLPs per animal twice with an interval of 4 weeks, and animals were challenged 3 weeks later intramuscularly with 600 plaque-forming units of Zaire EBOV. Three animals were completely protected against EBOV challenge, while one vaccinated animal and the control animal died from infection. We suggest that KUN VLPs encoding GP/D637L represent a viable EBOV vaccine candidate.

Dates et versions

hal-01911487 , version 1 (02-11-2018)

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Citer

Oleg V. Pyankov, Sergey A. Bodnev, Olga G. Pyankova, Vladislav V. Solodkyi, Stepan A. Pyankov, et al.. A Kunjin Replicon Virus-like Particle Vaccine Provides Protection Against Ebola Virus Infection in Nonhuman Primates. Journal of Infectious Diseases, 2015, 212 Suppl 2, pp.S368-371. ⟨10.1093/infdis/jiv019⟩. ⟨hal-01911487⟩
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