Central role for ferritin in the day/night regulation of iron homeostasis in marine phytoplankton. - Archive ouverte HAL Access content directly
Journal Articles Proceedings of the National Academy of Sciences of the United States of America Year : 2015

Central role for ferritin in the day/night regulation of iron homeostasis in marine phytoplankton.

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Emmanuel Lesuisse
Christophe Six
Thibaut Léger
Jean-Michel Camadro
Chris Bowler
Stéphane Blain
  • Function : Author
  • PersonId : 976011

Abstract

In large regions of the open ocean, iron is a limiting resource for phytoplankton. The reduction of iron quota and the recycling of internal iron pools are among the diverse strategies that phytoplankton have evolved to allow them to grow under chronically low ambient iron levels. Phytoplankton species also have evolved strategies to cope with sporadic iron supply such as long-term storage of iron in ferritin. In the picophytoplanktonic species Ostreococcus we report evidence from observations both in the field and in laboratory cultures that ferritin and the main iron-binding proteins involved in photosynthesis and nitrate assimilation pathways show opposite diurnal expression patterns, with ferritin being maximally expressed during the night. Biochemical and physiological experiments using a ferritin knock-out line subsequently revealed that this protein plays a central role in the diel regulation of iron uptake and recycling and that this regulation of iron homeostasis is essential for cell survival under iron limitation.

Dates and versions

hal-01267693 , version 1 (04-02-2016)

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Hugo Botebol, Emmanuel Lesuisse, Robert Šuták, Christophe Six, Jean-Claude Lozano, et al.. Central role for ferritin in the day/night regulation of iron homeostasis in marine phytoplankton.. Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (47), pp.14652-7. ⟨10.1073/pnas.1506074112⟩. ⟨hal-01267693⟩
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